In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. Regulation of Tissue Responses The TWEAK Fn14 Pathway and other TNF TNFR Superfamily Members that Activate Noncanonical NFkB Signaling Book Review: Praise for Nic Sheff:- ‘Difficult to read and impossible to put down.’Chicago Tribune 'Nic Sheff's wrenching tale is told with electrifying honesty and insight.' Armistead Maupin Tweak is a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery and complements his father’s parallel memoir, Beautiful Boy. He paints an extraordinary picture for us of a person at odds with his past, with his family, with his substances, and with himself.
In a voice that is raw and honest, Nic spares no detail in telling us the compelling true story of his relapse and the road to recovery. It took a violent relapse one summer to convince him otherwise. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. In the years that followed, he would regularly smoke pot, do cocaine and ecstasy, and develop addictions to crystal meth and heroin.
But control was something I'd lost a long time ago.’ Nic Sheff was drunk for the first time at age 11. THE NEW YORK TIMES BESTSELLER NOW A MAJOR FILM, STARRING STEVE CARELL AND BAFTA AND GOLDEN GLOBE NOMINATED TIMOTHEE CHALAMET ‘It was like being in a car with the gas pedal slammed down to the floor and nothing to do but hold on and pretend to have some semblance of control.